Reaktion #48146

Reaktionsgleichung

[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

intermediate 2

[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

3,4-dichlorobenzeneboronic acid

→

title compound

[1-(3,4-Dichloro-phenyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn analogy to the procedure described for the synthesis of example 6

Vorschrift

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from [5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone (intermediate 2) and 3,4-dichlorobenzeneboronic acid. The title compound was obtained in 90% yield as yellow foam. MS (m/e): 516.2 (MH+, 100%).

Quelle