Reaktion #48142

Reaktionsgleichung

(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

Intermediate 1

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

3-cyanophenylboronic acid

→

title compound

3-[2-(4,4-Difluoro-piperidine-1-carbonyl)-5-(1-isopropyl-piperidin-4-yloxy)-indol-1-yl]-benzonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn analogy to the procedure described for the synthesis of example 6

Vorschrift

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (Intermediate 1) and 3-cyanophenylboronic acid. The title compound was obtained in 46% yield as yellow foam. MS (m/e): 507.3 (MH+, 100%).

Quelle