Reaktion #481249

Reaktionsgleichung

5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

INTERMEDIATE 1

5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

2chloro-5-fluorophenylboronic acid

INTERMEDIATE 2

1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

→

5-(2-Chloro-5-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

Reaktionsbedingungen

Vorschrift

5-(2-Chloro-5-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone was prepared from 5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone (INTERMEDIATE 1) and 2chloro-5-fluorophenylboronic acid by a procedure analogous to that described in INTERMEDIATE 2. Mass spectrum (ESI) 450.0 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.52 (dd, J=3.0 Hz, 8.0 Hz, 2H); 7.25-7.42 (m, 3H); 7.10 (dt, J=2.5 Hz, 1H); 6.47 (d. J=2.0 Hz, 1H); 5.91 (d, J=2.5 Hz, 1H); 3.70 (s, 3H), 2.62-2.89 (m 4H).

Quelle