Reaktion #481144

Reaktionsgleichung

7-methoxyquinolin-4-ol

Nitric acid

→

7-methoxy-3-nitroquinolin-4-ol

Ausbeute 62.1%

Lösungsmittel

propionic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated to reflux
2. 2
   TemperaturThe reaction mixture was refluxed for 2 hrs
3. 3
   SonstigeThe resulting precipitate was isolated by filtration
4. 4
   Waschenwashed with cold ethanol
5. 5
   Sonstigedried

Vorschrift

A mixture of 7-methoxyquinolin-4-ol (5.0 g, 28.5 mmol) and propionic acid (50 mL) was heated to reflux. Nitric acid (3.2 mL of 70%, 50 mmol) was added dropwise over a period of 15 minutes. The reaction mixture was refluxed for 2 hrs and then allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, washed with cold ethanol followed by hexanes and then dried to provide 3.9 g of 7-methoxy-3-nitroquinolin-4-ol as a gray solid.

Quelle