Reaktion #481120

Reaktionsgleichung

7-Methyl-3-nitro-4-quinolinol

ammonium hydroxide

hydrogen

→

3-amino-7-methyl-4-quinolinol

Ausbeute 84.1%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through a layer of Celite®
2. 2
   Filtrationfilter agent
3. 3
   Waschenthe filter cake was rinsed well with methanol
4. 4
   workup.ADDITIONThe filtrate was treated with charcoal
5. 5
   Einengenconcentrated under vacuum
6. 6
   Sonstigeto provide a fluffy pale green solid
7. 7
   SonstigeThis material was triturated with acetonitrile

Vorschrift

7-Methyl-3-nitro-4-quinolinol (11.8 g, 58 mmol), methanol (about 300 mL), ammonium hydroxide (50 mL), and palladium on carbon (1 g of 10%) were combined. The mixture was placed on a Parr apparatus under a 35-40 psi (2.4-2.8 Kg/cm2) hydrogen atmosphere for about 1 hour. The reaction mixture was filtered through a layer of Celite® filter agent and the filter cake was rinsed well with methanol. The filtrate was treated with charcoal and then concentrated under vacuum to provide a fluffy pale green solid. This material was triturated with acetonitrile to provide 8.5 g of 3-amino-7-methyl-4-quinolinol.

Quelle