Reaktion #48109
ord-087999f7e0d549caa6d74fe79b97b3d8
Reaktionsgleichung
4-difluoromethyl-1-iodo-benzene
iPrMgCl
trimethyl borate
→
4-Difluoromethyl-phenylboronic acid
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
In a departure from the procedure described above the compound is prepared from 4-difluoromethyl-1-iodo-benzene (prepared from 4-iodobenzaldehyde using diethylaminosulfurtrifluoride (DAST) in dichloromethane) using iPrMgCl to generate the arylmetal compound and trapping this intermediate with trimethyl borate.