Reaktion #48108

ord-1be23ea1523a4716b40cd994300a4a50

Reaktionsgleichung

FC(F)Oc1ccc(I)cc1
4-difluoromethoxy-1-iodo-benzene
C[CH](C)[Mg][Cl]
iPrMgCl
COB(OC)OC
trimethyl borate
OB(O)c1ccc(OC(F)F)cc1
4-Difluoromethoxy-phenylboronic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a departure from the procedure described above the compound is prepared from 4-difluoromethoxy-1-iodo-benzene using iPrMgCl to generate the arylmetal compound and trapping this intermediate with trimethyl borate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07745414B2uspto-grants-2010_06