Reaktion #481032

ord-caf7523784c8430783e440b062e4c6e6

Reaktionsgleichung

O=C(c1cc(O)c(O)c(O)c1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1
5-{[4-(4-nitrophenyl)-1-piperazinyl]carbonyl}-benzene-1,2,3-triol
CC(C)(C)c1cc(C(=O)NCc2ccc([N+](=O)[O-])cc2)cc(C(C)(C)C)c1O
3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide
→
Nc1ccc(N2CCN(C(=O)c3cc(O)c(O)c(O)c3)CC2)cc1
5-{[4-(4-aminophenyl)-1-piperazinyl]carbonyl}-benzene-1,2,3-triol
Ausbeute 61.0%

Edukte

—
intermediate 2.2
O=C(c1cc(O)c(O)c(O)c1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1
5-{[4-(4-nitrophenyl)-1-piperazinyl]carbonyl}-benzene-1,2,3-triol
CC(C)(C)c1cc(C(=O)NCc2ccc([N+](=O)[O-])cc2)cc(C(C)(C)C)c1O
3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeA beige powder is obtained with a yield of 61%
  2. 2
    SonstigeThis is used directly in the following stage without additional purification

Vorschrift

The experimental protocol used is the same as that described for intermediate 2.2, with 5-{[4-(4-nitrophenyl)-1-piperazinyl]carbonyl}-benzene-1,2,3-triol replacing the 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide. A beige powder is obtained with a yield of 61%. This is used directly in the following stage without additional purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06809088B2uspto-grants-2004_10