Reaktion #48098

Reaktionsgleichung

water

4-bromo-3-chloromethyl-1-iodo-benzene

Phenol

NaI

→

4-Bromo-1-iodo-3-phenoxymethyl-benzene

Lösungsmittel

acetone

KOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe resulting mixture is extracted with ethyl acetate
2. 2
   SonstigeThe combined extracts are dried
3. 3
   Sonstigethe solvent is evaporated under reduced pressure
4. 4
   SonstigeThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1)

Vorschrift

Phenol (13 g) dissolved in 4 M KOH solution (60 mL) is added to 4-bromo-3-chloromethyl-1-iodo-benzene (41.0 g) dissolved in acetone (50 mL). NaI (0.5 g) is added and the resulting mixture is stirred at 50° C. overnight. Then, water is added and the resulting mixture is extracted with ethyl acetate. The combined extracts are dried and the solvent is evaporated under reduced pressure. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1).

Quelle