Reaktion #480913

ord-5335c99af6884d2a86ba1a01fc444d67

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1
4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)N1CCN(c2ncc(Br)cn2)CC1
4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
OB(O)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)benzeneboronic acid
→
CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(C(F)(F)F)cc3)cn2)CC1
title compound
Ausbeute 95.0%
CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(C(F)(F)F)cc3)cn2)CC1
4-[5-(4-Trifluoromethylphenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
Ausbeute 95.0%

Edukte

CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1
4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)N1CCN(c2ncc(Br)cn2)CC1
4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
OB(O)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)benzeneboronic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.346 g) and 4-(trifluoromethyl)benzeneboronic acid (0.211 g), to yield the title compound as a grey solid (0.392 g, 95%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06809100B2uspto-grants-2004_10