Reaktion #480902

ord-ba4d2f23235b412f94001f315bb331a1

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1
4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)N1CCN(c2ncc(Br)cn2)CC1
4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
c1cncc(B2OCCCO2)c1
pyridine-3-boronic acid 1,3-propanediol cyclic ester
→
CC(C)(C)OC(=O)N1CCN(c2ncc(-c3cccnc3)cn2)CC1
4-(5-Pyridin-3-ylpyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
Ausbeute 99.0%
CC(C)(C)OC(=O)N1CCN(c2ncc(-c3cccnc3)cn2)CC1
title compound
Ausbeute 99.0%

Edukte

CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1
4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)N1CCN(c2ncc(Br)cn2)CC1
4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
c1cncc(B2OCCCO2)c1
pyridine-3-boronic acid 1,3-propanediol cyclic ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.403 g) and pyridine-3-boronic acid 1,3-propanediol cyclic ester (0.211 g), to yield the title compound as an orange solid (0.399 g, 99%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06809100B2uspto-grants-2004_10