Reaktion #480872

Reaktionsgleichung

4-Iodomethyltetrahydropyran-4-carboxylic acid methyl ester

potassium thioacetate

→

title compound

Ausbeute 97.0%

4-Acetylsulfanylmethyltetrahydropyran-4-carboxylic acid methyl ester

Ausbeute 97.0%

Lösungsmittel

water

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with diethyl ether (4×25 ml)
2. 2
   WaschenThe combined organics were washed with saturated sodium bicarbonate solution (3×20 ml) and brine (20 ml)
3. 3
   Trocknendried (MgSO4)
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated under reduced pressure

Vorschrift

4-Iodomethyltetrahydropyran-4-carboxylic acid methyl ester (3.05 g) was dissolved in N,N-dimethylformamide (20 ml) at room temperature and potassium thioacetate (1.47 g) added. The mixture was stirred for 18 hours then diluted with water (50 ml) and extracted with diethyl ether (4×25 ml). The combined organics were washed with saturated sodium bicarbonate solution (3×20 ml) and brine (20 ml), then dried (MgSO4), filtered and evaporated under reduced pressure to give the title compound as a yellow solid (2.42 g, 97%).

Quelle