Reaktion #480696

Reaktionsgleichung

MeOH

1,1′-carbonyldiimidazole

4-nitrophenylbutyric acid

4-hydroxydiphenylamine

→

4-anilinophenyl 4-(4-nitrophenyl)butanoate

Ausbeute 89.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent is evaporated under vacuum
2. 2
   SonstigeThe evaporation residue is purified on a silica column (eluent: Heptane/AcOEt: 100/0 to 80/20)
3. 3
   SonstigeA yellow solid is obtained with a yield of 89%

Vorschrift

0.98 g (6.02 mmol) of 1,1′-carbonyldiimidazole is slowly added at 20° C. to a solution of 1.25 g (5.96 mmol) of 4-nitrophenylbutyric acid in 25 ml CH2Cl2. The reaction mixture is agitated for 30 minutes before the addition of 1 g (5.42 mmol) of 4-hydroxydiphenylamine. After agitation for 3 hours, the reaction is stopped by the addition of 3 ml of MeOH and the solvent is evaporated under vacuum. The evaporation residue is purified on a silica column (eluent: Heptane/AcOEt: 100/0 to 80/20). A yellow solid is obtained with a yield of 89%.

Quelle