Reaktion #480625

Reaktionsgleichung

N-[[1-(4-methoxyphenyl)cyclohexyl]carbonyl]-4-nitro-L-phenylalanine

N-[[1-(4-Methoxyphenyl)Cyclohexyl]Carbonyl]-4-Nitro-L-Phenylalanine

SnCl2.2H2O

→

[(1-(4-methoxyphenyl)cyclohexyl]carbonyl]-L-phenylalanine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONIn a 20 mL scintillation vial was added Wang resin
2. 2
   FiltrationThe resulting resin was collected by filtration
3. 3
   Waschenwas washed with DMF, isopropyl alcohol, dichloromethane, and ether

Vorschrift

In a 20 mL scintillation vial was added Wang resin linked N-[[1-(4-methoxyphenyl)cyclohexyl]carbonyl]-4-nitro-L-phenylalanine (241 mg, 0.14 mmol) prepared in Example 140 and 2 mL of a solution of 2M SnCl2.2H2O in DMF. The reaction mixture was shaken overnight at room temperature. The resulting resin was collected by filtration and was washed with DMF, isopropyl alcohol, dichloromethane, and ether to yield 243 mg (0.14 mmol) of 4-amino-N-[[(1-(4-methoxyphenyl)cyclohexyl]carbonyl]-L-phenylalanine on Wang resin.

Quelle