Reaktion #4804

Reaktionsgleichung

5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole

triethylamine

POCl3

Na2CO3

→

title compound

5-Cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole

Lösungsmittel

CH2Cl2

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Sonstigewas separated
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated in vacuo
5. 5
   workup.ADDITIONThe residue was treated with ether
6. 6
   Sonstigedecanted
7. 7
   Sonstigethe solution was evaporated

Vorschrift

A stirred solution of 5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole (60 mmol) and triethylamine (176 mmol) in CH2Cl2 (100 ml) was charged dropwise with POCl3 (60 mmol) at 0° C. The mixture was then left for 30 min. with stirring at 0° C., whereafter a solution of Na2CO3 (60 mmol) in H2O (50 ml) was added. The mixture was heated to room temperature, whereafter the organic phase was separated, dried and evaporated in vacuo. The residue was treated with ether, decanted and the solution was evaporated to give the title compound as an oil.

Quelle