Reaktion #48026

Reaktionsgleichung

N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridine-carboximidamide

triethylamine

triethylamine

palmitoylchloride

palmitoyl chloride

→

N-[2-palmitoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide monohydrochloride

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe solution was extracted
2. 2
   Trocknenwith water, 5% acetic acid and water, successively, dried over anh. sodium sulfate
3. 3
   Sonstigeevaporated to dryness

Vorschrift

14.7 g (52.8 mmol) of N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridine-carboximidamide [Hung. Pat. 177.578 (1976)] was dissolved in 160 ml of chloroform. 7.7 ml (55 mmol) of triethylamine was added, followed by dropwise addition of a solution of palmitoyl chloride (14.7 g; 56.5 mmol) in 85 ml of chloroform. The mixture was stirred overnight at room temperature. Next day further amount of 3.8 ml of triethylamine and 7.4 g of palmitoylchloride was added, and the stirring was continued for one more day. The solution was extracted then with water, 5% acetic acid and water, successively, dried over anh. sodium sulfate, and evaporated to dryness.

Quelle