Reaktion #48020

Reaktionsgleichung

trichloroisocyanuric acid

trimethylpyrazine

→

(Chloromethyl)dimethylpyrazine

Lösungsmittel

dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturmaintained
2. 2
   TemperaturThe reaction mixture is refluxed for 6 hours
3. 3
   Filtrationfiltered
4. 4
   EinengenThe filtrate is concentrated under reduced pressure
5. 5
   Filtrationfiltered again
6. 6
   Einengenconcentrated under reduced pressure
7. 7
   Sonstige9.6 g of methyldimethylpyrazine chloride are recovered in the form of a mixture, which
8. 8
   Sonstigeis used without further purification in the following step

Vorschrift

7.6 g (32.74 mmol) of trichloroisocyanuric acid are added, over 1 hour, to a solution, maintained at reflux, of 10 g of trimethylpyrazine (81.85 mmol) in 820 ml of dichloroethane. The reaction mixture is refluxed for 6 hours and then cooled to 20° C., stirred for a further 12 hours and filtered. The filtrate is concentrated under reduced pressure, taken up in 200 ml of ethyl ether, filtered again and then concentrated under reduced pressure. 9.6 g of methyldimethylpyrazine chloride are recovered in the form of a mixture, which is used without further purification in the following step.

Quelle