Reaktion #480047

Reaktionsgleichung

Triethyl borate

5-benzyloxy-2-bromo-4-ethyl-1-methoxybenzene

n-butyl lithium

ether

→

4-benzyloxy-5-ethyl-2-methoxy-phenylboronic acid

Lösungsmittel

THF

tetrahydrofuran

glyme

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to about room temperature

Vorschrift

The resulting 5-benzyloxy-2-bromo-4-ethyl-1-methoxybenzene (4) is allowed to react with n-butyl lithium in a polar solvent such as ether, glyme or tetrahydrofuran (THF), preferably THF, at a temperature of about −78° C. Triethyl borate is then added to the reaction mixture, and the reaction mixture is allowed to stir at a temperature of about −78° C. The reaction mixture is then allowed to warm to about room temperature. The reaction yields 4-benzyloxy-5-ethyl-2-methoxy-phenylboronic acid (5).

Quelle