Reaktion #48004

Reaktionsgleichung

(2-aminoindan-2-yl)methanol

phthalic anhydride

→

2-(2-hydroxymethylindan-2-yl)-isoindole-1,3-dione

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with chloroform
2. 2
   TrocknenThe organic phase is dried (Na2SO4)
3. 3
   Sonstigeevaporated

Vorschrift

A mixture of (2-aminoindan-2-yl)methanol (0.407 g, 2.50 mmol) and phthalic anhydride (0.369 g, 2.50 mmol) is heated at 160° C. for 40 minutes. The reaction mixture is poured into water and extracted with chloroform. The organic phase is dried (Na2SO4) and evaporated to afford 2-(2-hydroxymethylindan-2-yl)-isoindole-1,3-dione, MH+294.

Quelle