Reaktion #48003

Reaktionsgleichung

Lithium aluminium hydride

2-aminoindan-2-carboxylic acid

→

(2-aminoindan-2-yl)methanol

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched sequentially with water (0.9 ml), 2 M NaOH (0.9 ml) and further water (0.9 ml)
2. 2
   workup.ADDITIONMgSO4 is added
3. 3
   Filtrationthe resultant suspension is filtered
4. 4
   SonstigeThe filtrate is evaporated

Vorschrift

Lithium aluminium hydride (1 M solution in ether, 23.7 ml, 23.7 mmol) is added to a solution of 2-aminoindan-2-carboxylic acid (J. Med. Chem. 1991, 34, 3125; 2.26 g, 12.8 mmol) in ether (150 ml). The reaction is stirred for 2 hours at ambient temperature and quenched sequentially with water (0.9 ml), 2 M NaOH (0.9 ml) and further water (0.9 ml). MgSO4 is added and the resultant suspension is filtered. The filtrate is evaporated to afford (2-aminoindan-2-yl)methanol, MH+164.

Quelle