Reaktion #47992

Reaktionsgleichung

2,2′,4-Trimethoxybenzophenone oxime

ammonia

Ammonium acetate

→

title compound

C-(2,4-Dimethoxyphenyl)-C-(2-methoxyphenyl)methylamine

Lösungsmittel

ethanol

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction is heated
2. 2
   Temperaturto reflux for 4 hours
3. 3
   Filtrationfiltered through a Celite™
4. 4
   Filtrationfilter
5. 5
   SonstigeEvaporation

Vorschrift

2,2′,4-Trimethoxybenzophenone oxime (6 g, 20.9 mmol) is dissolved in ethanol (30 ml) and concentrated aqueous ammonia (150 ml). Ammonium acetate (0.81 g, 10.45 mmol) is added, followed by zinc powder (6.79 g, 104 mmol). The reaction is heated to reflux for 4 hours, cooled to ambient temperature, diluted with ethyl acetate and filtered through a Celite™ filter. Evaporation affords the title compound. δH 3.78 (s 3H), 3.80 (s 3H), 3.82 (s 3H), 5.62 (s 3H), 6.40-6.50 (m 2H), 6.85-9.95 (m 2H), 7.10 (d J 8), 7.20-7.30 (m 2H)

Quelle