Reaktion #47972

Reaktionsgleichung

N-[4-chloro-2-(4-bromobenzoyl)phenyl]-1H-imidazole-1-carboxamide

2,2,2-trifluoroethylamine

→

6-chloro-4-(4-bromophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction was cooled to ambient temperature
2. 2
   Einengenconcentrated in vacuo
3. 3
   SonstigeThe light yellow foam was partitioned between n-butyl chloride (15 mL) and aqueous 10% citric acid (15 mL) with vigorous stirring
4. 4
   FiltrationThe resulting precipitate was collected by vacuum filtration

Vorschrift

To a solution of N-[4-chloro-2-(4-bromobenzoyl)phenyl]-1H-imidazole-1-carboxamide (4.0 g, 9.9 mmol) in THF (20 mL) was added 2,2,2-trifluoroethylamine (1.1 g, 10.9 mmol). The reaction was heated to 50° C. After 19 h at 50° C., the reaction was cooled to ambient temperature and concentrated in vacuo. The light yellow foam was partitioned between n-butyl chloride (15 mL) and aqueous 10% citric acid (15 mL) with vigorous stirring. The resulting precipitate was collected by vacuum filtration to give 6-chloro-4-(4-bromophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one as a white solid. 1H NMR (CDCl3, 500 MHz) δ 7.98 (s, 1H); 7.50 (br d, 2H, J=8.79 Hz); 7.34 (br d, 2H, J=8.79 Hz); 7.22 (m, 2H); 6.97 (dd, J=1.46 and 7.57 Hz, 1H); 4.35 (dq, 1H, J=8.78 and 16 Hz); 3.53 (dq, 1H, J=8.55 and 17 Hz); 3.22 (s, 1H). MS (Electrospray): m/z M+Na, Br=79, 457.0

Quelle