Reaktion #479591

ord-26c16c92a2884acfb57e33b9120adbc1

Reaktionsgleichung

N#Cc1ccccc1Oc1ccc(NCc2cccnc2)cc1
N-(4-(2-cyanophenoxy)phenyl)pyridin-3-ylmethylamine
CCS(=O)(=O)Cl
ethanesulfonyl chloride
→
CCS(=O)(=O)N(Cc1cccnc1)c1ccc(Oc2ccccc2C#N)cc1
N-(4-(2-Cyanophenoxy)phenyl)-N-(ethanesulfonyl)pyrid-3-ylmethylamine

Edukte

N#Cc1ccccc1Oc1ccc(NCc2cccnc2)cc1
N-(4-(2-cyanophenoxy)phenyl)pyridin-3-ylmethylamine
CCS(=O)(=O)Cl
ethanesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigepurifying via preparative HPLC
  2. 2
    Wascheneluting with 98:2 to 96:4 DCM/MeOH

Vorschrift

Using the method of Example 342 using N-(4-(2-cyanophenoxy)phenyl)pyridin-3-ylmethylamine and ethanesulfonyl chloride (Aldrich) and purifying via preparative HPLC eluting with 98:2 to 96:4 DCM/MeOH. Anal Calcd for C21H19N3O3S.0.2H2O: C, 63.52; H, 4.92; N, 10.58. Found: C, 63.51; H, 4.79; N, 10.55. MS found 394.0 [M+H]+

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06800651B2uspto-grants-2004_10