Reaktion #47936

Reaktionsgleichung

KHSO4

2,4-dihydroxypyridine

K2CO3

I2

→

2,4-dihydroxy-3-iodopyridine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGWith continued stirring
2. 2
   Temperaturheating
3. 3
   SonstigeWhen the solid I2 was consumed
4. 4
   Temperaturthe mixture was cooled
5. 5
   FiltrationThe precipitate was collected by filtration
6. 6
   Waschenrinsed with water

Vorschrift

A mixture of 2,4-dihydroxypyridine (1.0 eq), K2CO3 (1.0 eq), and water was stirred at 100° C. so that it became homogeneous. With continued stirring and heating, I2 (1.0 eq) was added in portions, causing the evolution of gas. When the solid I2 was consumed, the mixture was cooled and acidified with aqueous KHSO4 (1.0 eq), generating a precipitate. The precipitate was collected by filtration, rinsed with water, and stored under high vacuum, to give 2,4-dihydroxy-3-iodopyridine.

Quelle