Reaktion #478682

Reaktionsgleichung

2-(3,5-dibromophenyl)benzo[d]thiazole

pyridine-3-boronic acid

potassium carbonate

→

2-(3-bromo-5-(pyridin-3-yl)phenyl)benzo[d]thiazole

Lösungsmittel

tetrahydrofuran H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONmixed in a volume ratio of 4/1
2. 2
   SonstigeThe solution was reacted at 80° C. for 12 hours
3. 3
   ExtraktionThe acquired reactant was extracted with ethyl acetate
4. 4
   workup.ADDITIONtreated under reduced pressure
5. 5
   Sonstigeto remove the solvent
6. 6
   SonstigeThe extract was separated through a column
7. 7
   Sonstigedried
8. 8
   Sonstigeobtaining 2.54 g (Y=54%) of a white solid

Vorschrift

4.74 g (12.8 mmol) of 2-(3,5-dibromophenyl)benzo[d]thiazole) according to Synthesis Example 5, 1.89 g (15.4 mmol) of pyridine-3-boronic acid, 0.44 g (3 mol %) of tetrakis(triphenylphosphine)palladium (0), and 5.31 g (38.4 mmol) of potassium carbonate were dissolved in 50 ml of tetrahydrofuran/H2O mixed in a volume ratio of 4/1. The solution was reacted at 80° C. for 12 hours. The acquired reactant was extracted with ethyl acetate and treated under reduced pressure to remove the solvent. The extract was separated through a column and dried, obtaining 2.54 g (Y=54%) of a white solid.

Quelle