Reaktion #478544

Reaktionsgleichung

tetrahydrofuran

hexane

n-butyllithium

→

(indenyl)ethane

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 500 mL three-neck flask replaced with nitrogen
2. 2
   Temperaturcooled in an ice bath
3. 3
   TemperaturWhile this solution was cooled in a water bath
4. 4
   SonstigeAfter the organic layer was separated
5. 5
   Extraktionthe aqueous layer was extracted with ethyl acetate
6. 6
   Waschenwashed with an aqueous saturated sodium chloride solution two times
7. 7
   Trocknendried with sodium sulfate
8. 8
   workup.DISTILLATIONVolatile components were distilled off under reduced pressure
9. 9
   Sonstigethe resulting yellow oily product was purified by column chromatography (
10. 10
    Sonstigeheptane/methylene chloride v/v=9/1), and recrystallized with ethanol/methylene chloride
11. 11
    SonstigeYield amount 9.1 g (purity>98%, 24 mmol, yield 57%)

Vorschrift

A 500 mL three-neck flask replaced with nitrogen was charged with 21.6 g (purity 72%, 42 mmol) of the yellow oily product and 274 mL of tetrahydrofuran, and cooled in an ice bath, and then 88.5 mL (1.59 M, 141 mmol) of a hexane solution of n-butyllithium was added dropwise. The color of the solution was turned from colorless to yellow. The temperature of this solution was gradually raised to room temperature, and the solution was further stirred for 1 hour. While this solution was cooled in a water bath, 137 mL of distilled water was added dropwise. After the organic layer was separated, the aqueous layer was extracted with ethyl acetate. The separated organic layer and the extract were combined, washed with an aqueous saturated sodium chloride solution two times, and dried with sodium sulfate. Volatile components were distilled off under reduced pressure, and the resulting yellow oily product was purified by column chromatography (developing solvent: heptane/methylene chloride v/v=9/1), and recrystallized with ethanol/methylene chloride. Based on the following 1H NMR (400 MHz, CDCl3) data, the resulting pale yellow solid was identified to be (5,6,7,8-tetrahydro-5,5,8,8-tetramethylbenz-f-inden-3-yl) (inden-3-yl)ethane. Yield amount 9.1 g (purity>98%, 24 mmol, yield 57%).

Quelle