Reaktion #47848

Reaktionsgleichung

4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine

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title compound

Ausbeute 85.6%

2-(methylsulfonyl)thieno[2,3-d]pyrimidine

Ausbeute 85.6%

Lösungsmittel

ethyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas bubbled for 5 minutes
2. 2
   workup.ADDITIONTo this solution was added 10% palladium on activated charcoal (15 g)
3. 3
   SonstigeTo the resulting mixture was bubbled hydrogen gas over night
4. 4
   FiltrationThe reaction mixture was filtered through Celite
5. 5
   EinengenThe filtrate was concentrated

Vorschrift

To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.

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