Reaktion #47844

Reaktionsgleichung

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

cyclohexylamine

→

titled compound

Ausbeute 24.0%

1-cyclohexylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Ausbeute 24.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was removed under a reduced pressure
2. 2
   SonstigeThe resulting residue was purified by flash chromatography

Vorschrift

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.27 mmol) obtained in Example 18 was dissolved in THF (10 mL), and cyclohexylamine (132.86 mg, 0.15 mL, 1.34 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 25 mg of the titled compound (yield: 24%).

Quelle