Reaktion #47842

Reaktionsgleichung

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

morpholine

→

titled compound

Ausbeute 83.0%

6-methoxy-1-morpholine-4-yl-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Ausbeute 83.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was removed under a reduced pressure
2. 2
   SonstigeThe resulting residue was purified by flash chromatography

Vorschrift

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (10 mg, 0.40 mmol) obtained in Example 18 was dissolved in THF (15 mL), and morpholine (175.01 mg, 0.18 mL, 2.01 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 126 mg of the titled compound (yield: 83%).

Quelle