Reaktion #478353

Reaktionsgleichung

chlorotrimethylsilane

dichloromethane

diisopropyl ether

→

(3-Chloropropoxy)trimethylsilane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturmaintaining the temperature between 0° C. and 5° C
2. 2
   Filtrationtriethylamine hydrochloride is filtered
3. 3
   Waschenwashing the pad with diisopropyl ether
4. 4
   EinengenThe filtrate is concentrated at 38° C. under reduced pressure
5. 5
   workup.DISTILLATIONthe product is purified by distillation (0-5 mmHg, 70° C.)

Vorschrift

A solution of chlorotrimethylsilane (126.40 g, 1.164 mol) in dichloromethane (300 L) is then added dropwise maintaining the temperature between 0° C. and 5° C. When the conversion is complete, diisopropyl ether (600 mL) is added and triethylamine hydrochloride is filtered washing the pad with diisopropyl ether. The filtrate is concentrated at 38° C. under reduced pressure and the product is purified by distillation (0-5 mmHg, 70° C.). (3-Chloropropoxy)trimethylsilane is obtained as a colourless liquid (144.57 g, 0.867 mol, 82%).

Quelle