Reaktion #47828

Reaktionsgleichung

1-Hydroxyimino-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

1-hydroxyimino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

→

titled compound

Ausbeute 82.2%

1-amino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Ausbeute 82.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewhile providing H2 gas
2. 2
   Filtrationfiltered through celite
3. 3
   Einengenconcentrated under a reduced pressure
4. 4
   SonstigeThe resulting residue was purified by flash chromatography

Vorschrift

1-Hydroxyimino-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1.00 g, 3.09 mmol) obtained in Step 1 was dissolved in methanol (100 mL), and 10%-palladium (583 mg) was added thereto. The mixture was stirred for 15 hrs at RT while providing H2 gas thereto using a balloon, filtered through celite, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 786 mg of the titled compound (yield: 82%).

Quelle