Reaktion #47825

Reaktionsgleichung

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

1-bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

methanol

→

titled compound

Ausbeute 24.0%

1,6-dimethoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Ausbeute 24.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   SonstigeThe organic layer was separated
3. 3
   Einengenconcentrated under a reduced pressure
4. 4
   SonstigeThe resulting residue was purified by flash chromatography

Vorschrift

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (60 mg, 0.18 mmol) obtained in Step 1 was dissolved in methanol (10 mL), silver nitrate (37.20 mg, 0.22 mmol) was added thereto, stirred for 3 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 14 mg of the titled compound (yield: 24%).

Quelle