Reaktion #478239

Reaktionsgleichung

4-piperidone monohydrate hydrochloride salt

2-bromoethyl methyl ether

K2CO3

→

1-(2-methoxy-ethyl)piperidin-4-one

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux overnight
3. 3
   SonstigeReaction
4. 4
   Extraktionextracted into dichloromethane (50 ml)
5. 5
   Waschenwashed with water (2×50 ml)
6. 6
   Trocknendried (MgSO4)
7. 7
   Sonstigeevaporated in vacuo

Vorschrift

To a solution of 4-piperidone monohydrate hydrochloride salt (2.2 g, 14.32 mmol, 1 eq) in acetonitrile, 2-bromoethyl methyl ether (5.9 ml, 28.6 mmol, 2 eq), and K2CO3 (2 eq) was added and heated at reflux overnight. Reaction extracted into dichloromethane (50 ml), washed with water (2×50 ml), dried (MgSO4), and evaporated in vacuo to give 1-(2-methoxy-ethyl)piperidin-4-one as a yellow oil.

Quelle