Reaktion #47818

Reaktionsgleichung

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

1-oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

phenylmagnesium chloride

→

titled compound

Ausbeute 90.3%

1-hydroxy-1,3-diphenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

Ausbeute 90.3%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeUpon the completion of the reaction
2. 2
   Waschenthe mixture washed with saturated saline
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   SonstigeThe organic layer was separated
5. 5
   Trocknendried over anhydrous MgSO4
6. 6
   Einengenconcentrated under a reduced pressure
7. 7
   SonstigeThe resulting residue was purified by flash chromatography

Vorschrift

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile (350 mg, 0.878 mmol) obtained in Step 1 was dissolved in THF, and phenylmagnesium chloride (0.483 mL, 0.966 mmol) was added thereto, followed by stirring for 3 hrs at 0° C. Upon the completion of the reaction, the mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 378 mg of the titled compound (yield: 90%).

Quelle