Reaktion #47817

Reaktionsgleichung

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester

p-toluenesulfonic acid

→

titled compound

Ausbeute 62.1%

1-oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

Ausbeute 62.1%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 24 hrs
2. 2
   WaschenThe resulting mixture washed with sodium bicarbonate
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   SonstigeThe organic layer was separated
5. 5
   Trocknendried over anhydrous MgSO4
6. 6
   Einengenconcentrated under a reduced pressure
7. 7
   SonstigeThen, the resulting residue was purified by flash chromatography

Vorschrift

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester (2 g, 4.85 mmol) obtained in Example 7 was dissolved in methanol, p-toluenesulfonic acid (92 mg, 0.49 mmol) was added thereto, and refluxed for 24 hrs. The resulting mixture washed with sodium bicarbonate and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. Then, the resulting residue was purified by flash chromatography to obtain 1.2 g of the titled compound (yield: 62%).

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