Reaktion #477897

Reaktionsgleichung

2,2-dimethyl-N-(5-methyl-1,3-thiazol-2-yl)propanamide

5-chloro-1,10-phenanthroline

2-bromo-5-methylthiophene

ammonium hydroxide water

cesium carbonate

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title compound

2,2-dimethyl-N-[(2Z)-5-methyl-3-(5-methylthien-2-yl)-1,3-thiazol-2(3H)-ylidene]propanamide

Lösungsmittel

1-methyl-2-pyrrolidinone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONIn a 4 mL vial charged with a stir bar
2. 2
   SonstigeA loose cap with septum
3. 3
   SonstigeThe mixture was purged with nitrogen gas a couple of times
4. 4
   workup.ADDITIONwas added to the solid mixture
5. 5
   SonstigeThe vial was capped
6. 6
   Sonstigeplaced on a heater/stirrer
7. 7
   FiltrationThe reaction was filtered
8. 8
   Einengenconcentrated to dryness
9. 9
   SonstigeThe residue was purified by reverse phase HPLC (C8, gradient 10-100% acetonitrile/water/0.1% trifluoroacetic acid)

Vorschrift

In a 4 mL vial charged with a stir bar, 2,2-dimethyl-N-(5-methyl-1,3-thiazol-2-yl)propanamide (62 mg, 0.3 mmol, Example 87A) was added, followed by copper(I) trifluoromethanesulfonate benzene complex (31 mg, 0.06 mmol), 5-chloro-1,10-phenanthroline (26 mg, 0.12 mmol) and cesium carbonate (107 mg, 0.33 mmol). A loose cap with septum was placed on the vial and then the vial was placed under vacuum in a vacuum oven for 30 minutes. The mixture was purged with nitrogen gas a couple of times. Then 2-bromo-5-methylthiophene (58 mg, 0.33 mmol) dissolved in 1-methyl-2-pyrrolidinone (1.0 mL) was added to the solid mixture. The vial was capped and placed on a heater/stirrer and heated to 120° C. overnight. Then 1 mL of a solution of concentrated ammonium hydroxide/water (1:2) was added. The reaction was filtered and concentrated to dryness. The residue was purified by reverse phase HPLC (C8, gradient 10-100% acetonitrile/water/0.1% trifluoroacetic acid) to provide the title compound.

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