Reaktion #477589

Reaktionsgleichung

4-Methyl-pyrazole-1-carboxylic acid tert-butyl ester

N-bromosuccinimide

benzoyl peroxide

→

title compound

4-Bromomethyl-pyrazole-1-carboxylic acid tert-butyl ester

Lösungsmittel

CCl4

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was heated
2. 2
   Temperaturto reflux
3. 3
   FiltrationThe mixture was filtered
4. 4
   Einengenconcentrated
5. 5
   Sonstigethe residue was purified by silica gel chromatography

Vorschrift

4-Methyl-pyrazole-1-carboxylic acid tert-butyl ester (0.875 g, 4.8 mmol), N-bromosuccinimide (0.897 g, 5.0 mmol), and benzoyl peroxide (0.058 g, 0.24 mmol) were combined in CCl4 (50 mL). The reaction was heated to reflux and stirred under a halogen lamp for 1 hour. The mixture was filtered and concentrated, and the residue was purified by silica gel chromatography to give the title compound, contaminated with a small amount of starting material.

Quelle