Reaktion #477556

Reaktionsgleichung

methanol

2-fluoro-4-hydroxybenzoic acid

sulfuric acid

→

title compound

Ausbeute 94.0%

methyl 2-fluoro-4-hydroxybenzoate

Ausbeute 94.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith heating
2. 2
   EinengenThe reaction solution was concentrated
3. 3
   Waschenthe resulting colorless crystals were washed with water
4. 4
   Sonstigedried

Vorschrift

A solution of 2-fluoro-4-hydroxybenzoic acid (50.0 g) and concentrated sulfuric acid (10 mL) in methanol (700 mL) was stirred at 90° C. for 16 hr with heating. The reaction solution was concentrated, and the resulting colorless crystals were washed with water, and dried to give the title compound (51 g, yield 94%) as colorless crystals.

Quelle