Reaktion #477535

Reaktionsgleichung

DMF

2-(4-Fluorophenyl)acetohydrazide

3-(benzyloxy)-N,9,9-trimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carbothioamide

MeI

→

title compound

Ausbeute 22.4%

2-(5-(4-Fluorobenzyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-hydroxy-9,9-dimethyl-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one

Ausbeute 22.4%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was then cooled to ambient temperature
2. 2
   Einengenconcentrated in vacuo
3. 3
   Temperaturthe slurry was heated at 140° C. (oil bath)
4. 4
   Temperaturthe reaction was cooled to ambient temperature
5. 5
   Einengenconcentrated in vacuo
6. 6
   workup.ADDITIONThe residue was added to a saturated aqueous solution of NaHCO3
7. 7
   Extraktionextracted with CH2Cl2 (×3)
8. 8
   TrocknenThe combined CH2Cl2 extracts were dried (Na2SO4)
9. 9
   Einengenconcentrated in vacuo
10. 10
    workup.ADDITIONThe crude product was treated with DMF (˜1.5 mL)
11. 11
    workup.DISSOLUTIONto dissolve material
12. 12
    Filtrationthe insoluble portion was filtered
13. 13
    Waschenwashed with methanol

Vorschrift

To a solution of 3-(benzyloxy)-N,9,9-trimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carbothioamide (0.1 g, 0.278 mmol, 1.0 equiv) in acetonitrile (0.9 mL) under a nitrogen atmosphere, was added MeI (0.070 mL, 1.11 mmol, 4 equiv). The reaction was heated at 50° C. (oil bath) for 45 min. The reaction was then cooled to ambient temperature and concentrated in vacuo. 2-(4-Fluorophenyl)acetohydrazide (0.14 g, 0.84 mmol, 3 equiv) was then added to the residue followed by DMF (2 mL) and the slurry was heated at 140° C. (oil bath). After stirring 16 h, the reaction was cooled to ambient temperature and concentrated in vacuo. The residue was added to a saturated aqueous solution of NaHCO3 and extracted with CH2Cl2 (×3). The combined CH2Cl2 extracts were dried (Na2SO4) and then concentrated in vacuo. The crude product was treated with DMF (˜1.5 mL). After trying to dissolve material, the insoluble portion was filtered and washed with methanol to provide the title compound (0.024 g, 22% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 7.21 (dd, J=8.81, 5.29 Hz, 2H), 7.03 (t, J=8.69 Hz, 2H), 4.24 (s, 2H), 4.04 (q, J=2.77 Hz, 4H), 3.93 (s, 3H), 1.57 (s, 6H); LCMS (ES+, (M+H)+) m/z 386.22.

Quelle