Reaktion #47748

Reaktionsgleichung

4,5-Bis(bromomethyl)-3-hydroxy-2-methylpyridine

3,4-Bis(bromomethyl)-5-hydroxy-6-methylpyridine

water

→

3-Bromomethyl-5-hydroxy-4-hydroxymethyl-6-methylpyridine hydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was filtered
2. 2
   Sonstigeevaporated under vacuum
3. 3
   SonstigeThe obtained residue was crystallized from ethanol

Vorschrift

4,5-Bis(bromomethyl)-3-hydroxy-2-methylpyridine (2)(3 g, 0.008 mol) was stirred in water (24 ml) at 45-50° C. for 40 min. The solution was filtered and evaporated under vacuum. The obtained residue was crystallized from ethanol. The yield was 1.2 g (50%). The position of bromomethyl- in pyridine-ring was verified by qualitative analysis with 2,6-dichloroquinone-4-chloroimide (Harris and Folkers (1939) J. Am. Chem. Soc. 61: 247). M.p. 158-159° C.

Quelle