Reaktion #47744

Reaktionsgleichung

arecoline hydrochloride

HCl

→

product

Ausbeute 46.0%

Arecaidine hydrochloride

Ausbeute 46.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 250 ml flask equipped with a magnetic stirrer and a condenser
2. 2
   Temperaturat reflux for 6 hours
3. 3
   SonstigeThe solvents are evaporated off under reduced pressure
4. 4
   Sonstigeleaving a solid residue
5. 5
   SonstigeThe residue is recrystallized from a 95% ethanol/ether mixture in order

Vorschrift

In a 250 ml flask equipped with a magnetic stirrer and a condenser, arecoline hydrochloride (4 g; 20.9 mmol) is added to a solution of 50 ml of 95% ethanol and 60 ml of concentrated HCl. The mixture is heated at 100° C. for 12 hours then at reflux for 6 hours. The solvents are evaporated off under reduced pressure leaving a solid residue. The residue is recrystallized from a 95% ethanol/ether mixture in order to produce 1.69 g of product (Yield=46%) in the form of white crystals.

Quelle