Reaktion #47741

Reaktionsgleichung

1-benzyl-4-tertbutyloxycarbonylaminopiperidine

1-Benzyl-4-tertbutyloxycarbonylaminopiperidine

hydrogen

→

product

Ausbeute 91.0%

4-tert-Butyloxycarbonylaminopiperidine

Ausbeute 91.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtration on celite
2. 2
   Waschenwashing with methanol
3. 3
   Einengenthe medium is concentrated in order

Vorschrift

A solution of 1-benzyl-4-tertbutyloxycarbonylaminopiperidine 5 (7.95 g; 27.4 mmol) in 120 ml of MeOH is poured into a hydrogenation reactor. 10% Pd/c-based catalyst is added (1.46 g; 1.38 mmol) and the mixture is subjected to a hydrogen pressure of 3.5 bars (50 psi) for 24 hours in a Parr type shaker. After filtration on celite and washing with methanol, the medium is concentrated in order to produce 4.98 g (Yield=91%) of product in the form of white crystals.

Quelle