Reaktion #476837

Reaktionsgleichung

Intermediate 24

1-Benzylsulfanyl-3-bromo-2-trifluoromethyl-benzene

piperidin-2-one

→

1-(3-Benzylsulfanyl-2-trifluoromethyl-phenyl)piperidin-2-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis purified by chromatography on silica gel (n-heptane-ethyl acetate 4:1)

Vorschrift

Intermediate 24 (10.5 g, 30.24 mmol) was coupled with piperidin-2-one (3.597 g, 36.29 mmol) in close analogy to the procedure described in step 1.6). After workup the crude oil is purified by chromatography on silica gel (n-heptane-ethyl acetate 4:1).

Quelle