Reaktion #47645

Reaktionsgleichung

(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methoxy-butyric acid

diethyl ether

(trimethylsilyl)diazomethane

diethyl ether

→

(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methoxy-butyric acid methyl ester

Ausbeute 94.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a flask was placed
2. 2
   EinengenThe mixture was then concentrated

Vorschrift

In a flask was placed (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methoxy-butyric acid (500 mg, 1.41 mmol), diethyl ether (20 mL) and methanol (5 mL) and cooled to 0° C. in an ice bath. To this mixture was added a 2M solution of (trimethylsilyl)diazomethane in diethyl ether (1.41 mL, 2.82 mmol) dropwise. The mixture was stirred and warmed to 25° C. The mixture was then concentrated to afford (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methoxy-butyric acid methyl ester (489 mg, 94%) as a white solid.

Quelle