Reaktion #476434

Reaktionsgleichung

(−)-7-amino-5-benzyl-7-methyl-5-azaspiro[2.4]heptane D-mandelate

sodium hydroxide

→

title product

Ausbeute 122.5%

(−)-7-Amino-5-benzyl-7-methyl-5-azaspiro[2.4]heptane

Ausbeute 122.5%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThereafter, the toluene layer was separated
2. 2
   Waschenwashed with saturated brine
3. 3
   Trocknendried with sodium sulfate
4. 4
   SonstigeThe desiccant was removed through filtration
5. 5
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

To (−)-7-amino-5-benzyl-7-methyl-5-azaspiro[2.4]heptane D-mandelate (22.43 g, optical purity: 98% e.e.), 10% Aqueous sodium hydroxide and toluene were added, and the mixture was stirred at room temperature. Thereafter, the toluene layer was separated, washed with saturated brine, and dried with sodium sulfate. The desiccant was removed through filtration, and the filtrate was concentrated under reduced pressure, to thereby yield the title product as pale yellow oil (16.13 g, optical purity: 98% e.e.).

Quelle