Reaktion #47632

Reaktionsgleichung

2-benzyloxycarbonylamino-3-bicyclo[2.2.1]hept-2-yl-acrylic acid methyl ester

hydrogen

→

2-amino-3-bicyclo[2.2.1]hept-2-yl-propionic acid methyl ester

Ausbeute 70.1%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a flask was placed
2. 2
   Sonstigethe flask was fitted with a balloon
3. 3
   Filtrationfiltered through celite and
4. 4
   Einengenconcentrated in vacuo

Vorschrift

In a flask was placed 2-benzyloxycarbonylamino-3-bicyclo[2.2.1]hept-2-yl-acrylic acid methyl ester (491 mg, 1.49 mmol) and methanol (15 mL). To this mixture added 10% palladium on activated carbon (60 mg) and the flask was fitted with a balloon filled with hydrogen. The mixture was allowed to stir at 25° C. for 1 h and then filtered through celite and concentrated in vacuo to afford 2-amino-3-bicyclo[2.2.1]hept-2-yl-propionic acid methyl ester (206 mg, 70%) as a white solid.

Quelle