Reaktion #476102

Reaktionsgleichung

water

2-Bromopropane

K2CO3

2-nitroimidazole

→

1-isopropyl-2-nitro-1H-imidazole

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe contents were cooled to room temperature
2. 2
   Extraktionthe mixture was extracted with EtOAc (3×10 mL)
3. 3
   TrocknenThe combined extracts were dried over MgSO4
4. 4
   Filtrationfiltered
5. 5
   Sonstigethe solvent was removed in vacuo

Vorschrift

2-Bromopropane (7 mmol) and K2CO3 (13 mmol) were added to a solution of 2-nitroimidazole (4 mmol) in DMF (10 mL). The mixture was stirred at 60° C. for 4 h. The contents were cooled to room temperature and water (20 mL) was added and the mixture was extracted with EtOAc (3×10 mL). The combined extracts were dried over MgSO4, filtered and the solvent was removed in vacuo to afford 1-isopropyl-2-nitro-1H-imidazole. The product used for further transformation without further purification.

Quelle