Reaktion #475980

ord-a3649b51cef64e4aae791ee25dd811ad

Reaktionsgleichung

Nc1ccc(I)cc1F
4-iodo-2-fluoroaniline
O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2)nn1)c1ccc(Cl)s1
compound 35
O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2)nn1)c1ccc(Cl)s1
5-Chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide
→
O=C(NCc1cn(-c2ccc(I)cc2F)nn1)c1ccc(Cl)s1
title compound
O=C(NCc1cn(-c2ccc(I)cc2F)nn1)c1ccc(Cl)s1
5-Chloro-N-((1-(2-fluoro-4-iodophenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide

Edukte

Nc1ccc(I)cc1F
4-iodo-2-fluoroaniline
O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2)nn1)c1ccc(Cl)s1
compound 35
O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2)nn1)c1ccc(Cl)s1
5-Chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by the same procedure for compound 35 described in Example 290 in Scheme 5, using 4-iodo-2-fluoroaniline in place of 4-iodoaniline. MS found for C14H9ClFIN4OS as (M+H)+ 462.0, 464.0

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08377974B2uspto-grants-2013_02