Reaktion #47573

Reaktionsgleichung

(E)-3-phenoxy-but-2-enoic acid ethyl ester

N-bromosuccinimide

benzoyl peroxide

→

(E)-4-bromo-3-phenoxy-but-2-enoic acid ethyl ester

Ausbeute 74.5%

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeNitrogen gas was bubbled through the mixture for 5 min
2. 2
   Temperaturthe resulting mixture was heated
3. 3
   Temperaturto reflux for 4 h
4. 4
   Sonstigewas then placed in the refrigerator overnight
5. 5
   SonstigeThe solids formed
6. 6
   Sonstigewere removed by filtration
7. 7
   Einengenthe filtrate concentrated in vacuo
8. 8
   SonstigeThe crude product obtained
9. 9
   Sonstigewas purified

Vorschrift

To a stirred mixture of (E)-3-phenoxy-but-2-enoic acid ethyl ester (5.00 g, 0.024 mol) in carbon tetrachloride (20 mL) under a nitrogen atmosphere was added N-bromosuccinimide (6.50 g, 0.037 mol) and benzoyl peroxide (580 mg, 0.002 mol). Nitrogen gas was bubbled through the mixture for 5 min, and the resulting mixture was heated to reflux for 4 h. The reaction mixture was then placed in the refrigerator overnight. The solids formed were removed by filtration and the filtrate concentrated in vacuo. The crude product obtained was purified using flash column chromatography (silica gel (100-200 mesh), ethyl acetate/hexanes) to afford (E)-4-bromo-3-phenoxy-but-2-enoic acid ethyl ester (5.10 g, 74%) as a yellow oil.

Quelle