Reaktion #475696

Reaktionsgleichung

1-(benzyloxy)-2,5-difluoro-4-nitrobenzene

→

title compound

Ausbeute 99.0%

4-Amino-2,5-difluorophenol

Ausbeute 99.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter terminating
2. 2
   Sonstigethe reaction
3. 3
   Filtrationthe catalyst was filtered
4. 4
   workup.DISTILLATIONThe filtrate was distilled off under reduced pressure

Vorschrift

To a solution of 1-(benzyloxy)-2,5-difluoro-4-nitrobenzene (9.21 g) in methanol (300 ml) was added 10% palladium on carbon (921 mg), and the mixture was stirred at room temperature for 24 hours and 20 minutes under a hydrogen atmosphere. After terminating the reaction by substituting the atmosphere in the flask with nitrogen, the catalyst was filtered using Celite. The filtrate was distilled off under reduced pressure to give the title compound (4.96 g, 99%) as a brown solid.

Quelle